"The Towers hide the darkness of the day."
Skyscrapers, cities, factories. We have engineered humans to build these rotting metopoli so that we may feed more easily and exist in numbers. This concentration is one of the signs.
"When Lasombra's dreams come true."
The Lasombra Antediluvian is thought destroyed. This could mean the dreams of the clan or visions seen by 'Lasombra' before he was destroyed. The clan or its Antitribu must be asked.
"On the day when the moon runs red as blood and the sun rises black in the sky."
A scarlet moon and a solar eclipse in conjunction. The next full eclipse, wherever it falls may be the end time. The 'first day' when pollution and decay will spiral out of control. Animals will die and children will be deformed. We can already see this beginning.
"The time of thin blood which will mark Vampires that cannot beget, the clanless who will come to rule."
Caitiff Princes, those of no blood, adopted or otherwise must be prevented from gaining power so that we might at least stave off Gehenna. We also already see that those of the 14th and 15th generations are too weak of blood to produce more of our kind. we have spawned too many of ourselves, the elders have squandered their gift of life. Only Cain himself can grant sanction to create progeny.
"The Shadow which flies, the dragon that rises, the darkness which moves, the shadow of the moon, the angel that dies, the maiden who weeps, the children embraced, the clanless who run."
There are many interpretations. If any are true many of these are already happening. The Dragon could even be The Pendragon which has arisen in Britain, when else would it arise but Gehenna? The time when it is needed the most?
"And there will be a time when Sire will drive out childer, when sire will abandon childer to the sun's mercy."
This already happens. The Justicars and Princes must be curbed in their excesses of punishment.